Adverse Events Following Screening Eye Examination for Retinopathy of Prematurity in Premature Infants

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ESPR442
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Abstract: :

Background: Screening examination for retinopathy of prematurity (ROP) is recommended for high-risk premature infants. The ROP examination is stressful for vulnerable neonates and can cause adverse events including apnea, bradycardia, desaturation, increased respiratory support, and increased sepsis evaluation.  


Objectives: The objective of our study was to determine whether ROP screening examination increases the incidence of adverse events in preterm infants. 


Design/Methods: This was a retrospective analysis from a tertiary neonatal intensive care unit. We included preterm infants (less than or equal to 32 weeks gestation) born between March 2017 and December 2019 who survived until first eye examination. The number of episodes of apnea, bradycardia, and desaturation were compared 1 day before, on the day of examination, and 1 day after the examination. The cumulative adverse events, number of infants on mechanical ventilation, and number of infants requiring sepsis evaluation 3 days prior to and 3 days after the eye examination were also compared. 


Results: The study included 124 infants with median gestational age of 29 weeks (IQR, 27-31 weeks) and median birth weight of 1.2 kg (IQR, 0.83-1.45 kg). A total of 461 ophthalmologic examinations were performed. There was no significant difference in apnea, bradycardia, and desaturation 1 day before, on the day of examination, and one day after the examination (Table 2). Similarly, there were no significant differences in cumulative adverse events 3 days before and 3 days after an eye examination except for an increase in any event (apnea, bradycardia or desaturation). There was no difference in the number of infants on mechanical ventilation and the number of infants requiring sepsis evaluation 3 days before and 3 days after an eye examination.


Conclusions: In our study, screening ROP examination was not associated with increased adverse events. Isolated finding of an increase in any of apnea, bradycardia, desaturation 3 days after examination could be due to multiple comparison. 

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Thomas Jefferson Sidney Kimmel Medical College
Thomas Jefferson Sidney Kimmel Medical College
Thomas Jefferson University

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