Assessing the Temporality of Adverse Effects of the Two-Month Vaccination in the NICU

This submission has open access
Submission ID :
ESPR290
Submission Type
Submission Topic
Abstract: :

Introduction: Premature infants are at an increased risk of contracting vaccine-preventable diseases and experience worse morbidity and mortality outcomes. Evidence supports keeping premature infants on a regular vaccination schedule regardless of gestational age or birth weight, but the schedule is often delayed, in part because preterm infants experience an increased incidence of adverse events compared to term infants. The most recent literature points to a mix of findings regarding an increase in cardiorespiratory events after immunization with little data evaluating newer combination vaccines.

Objective: The aim of our study was to determine if the two-month immunization in the NICU contributes to an increased number of adverse events.

Methods: This was a retrospective, single-center, observational study with a target population of infants born at less than 32 weeks gestation at Thomas Jefferson University Hospital who received the two-month vaccination series in the NICU between 2017-2019. The primary outcome was the number of cardiorespiratory events (apnea, bradycardia, and desaturations), which was measured in the 72 hours before and after immunization. Our data collection source was EPIC medical records. We analyzed our data using the Generalized Estimating Equation (GEE) with Poisson link to compare the incidence between pre- and post-immunization events.

Results: Thirty-seven neonates met the inclusion criteria. The mean (SD) gestational age was 27.3±2.56 weeks and the mean birth weight was 989±313 grams (Table 1). The incidence rate ratio (IRR) between pre-and post-immunization was 2.1 for desaturation (95% CI: 1.21-3.63; p = 0.008), 3.5 for bradycardia (95% CI: 0.97-12.58; p = 0.05), and 1.33 for apnea (95% CI: 0.26-6.94; p = 0.732) (Table 2).

Conclusion: The results support links between immunization and increased risk of desaturation and bradycardia with the most recent formulations of the two-month immunization. This indicates that neonates should be closely monitored after receiving two-month immunizations.

Optional insertion of tables and or figures :
If the file does not load, click here to open/download the file.
If the file does not load, click here to open/download the file.
Thomas Jefferson Sidney Kimmel Medical College
Thomas Jefferson University
Thomas Jefferson University

Similar Abstracts by Type

Submission ID
Submission Title
Submission Topic
Submission Type
Corresponding Author
ESPR157
Clinical Research
Original science
Aditya Chhikara
ESPR302
Epidemiology
Original science
Natasha Jouk
ESPR74
Clinical Research
Original science
Alexandra Mazo